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KMID : 0366219890240020409
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Korean Journal of Hematology
1989 Volume.24 No. 2 p.409 ~ p.419
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A Study on the HBsAg and Anti-HBs in Primary School Children
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김상인/Sang In Kim
한규섭/조한익/김이우/김병국/오영철/조명준/Kyou Sup Han/Han Ik Cho/Yi Woo Kim/Byung Kook Kim/Young Chul Oh/Myung Joon Cho
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Abstract
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HBsAg and anti-HBs tests were performed on 585 primary school children in Seoul
area using enzyme-linked immunosorbent assay(ELISA). The results were analyzed
according to sex, schoolyear grade, and vaccination history and summarized as follows :
1. The positive rate of HBsAg was 4.1% and sexual difference was not noted.
2. The positive rate of anti-HBs was 69.0% and sexual difference was not noted.
3. anti-HBs of higher titers( > 10 IU/L) were found more often in females than in
males in the same conditions
4. The positive rate of anti-HBs and proportion of higher-titer anti-HBs were
significantly higher in children of higher schoolyear grade in the same conditions.
5. The positive rate of HBsAg in non-vaccinated children was 10.1% while it was
only 1.9% in vaccinated children. This difference was statistically significant(p<0.01).
6. In vaccinated children, the positive rate of anti-HBs was significantly higher than
in non-vaccinated children. In children who were vaccinated more than three times, the
titers of anti-HBs were significantly higher than those with one or two times of
vaccination histories.
7. Anti-HBs were found in 85% of the children with vaccination history and this
features maintained for 24 months. The positive rate declined slowly down to 65% after
5 years.
8. Among the children who were vaccinated more than three times, the positive rate
of HBsAg was 3.3% in males and 0% in females. This difference was statistically
significant(p< 0.05).
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